Rebekka K. Schneider

Cyclic uremia without kidney injury drives cardiovascular disease with rapid onset of immunosenescence and heart failure

This study establishes a mouse model of cyclic uremia without kidney injury, showing it drives cardiovascular disease and immunosenescence independently of traditional risk factors.

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

NicheSphere reveals Spp1⁺ macrophages as central hubs coordinating fibrotic remodeling in myeloproliferative neoplasms

This study identifies Spp1⁺ macrophages as key hubs coordinating fibrotic remodeling in myeloproliferative neoplasms using NicheSphere, a novel computational method for cell communication analysis.

Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

Wnt-dependent spatiotemporal reprogramming ofbone marrow niches drives fibrosis

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

Inhibition of JAK2V617F-Driven Neoplastic Endothelial Dysfunction by IFNα as a Novel Antifibrotic Mechanism

This study identifies JAK2V617F zygosity-specific vascular changes in MPN and shows IFNα inhibits EndMT, offering a novel antifibrotic mechanism.

Spatial multi-omic map of human myocardial infarction

This study generates a high-resolution spatial multi-omic map of human myocardial infarction by integrating single-cell gene expression, chromatin accessibility, and spatial transcriptomic data to reveal cellular zones of injury, repair, and remodeling.

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

This study uses human pluripotent stem cell-derived kidney organoids to model nephrotic syndrome, showing they can replicate podocyte injury and respond to genetic correction.

CrossTalkeR: Analysis and Visualisation of Ligand Receptor Networks

CrossTalkeR analyzes and visualizes ligand-receptor networks to identify changes in cell communication between two biological phenotypes using single-cell RNA-seq data.