Gabriele Lubatti

This study shows that M-CSF drives alveolar macrophage plasticity during development and CMV infection, increasing ISG expression and modulating infection susceptibility.

CIARA identifies markers of rare cell types from single-cell RNA-seq data, outperforming existing methods and discovering new cell populations in mouse and human samples.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.