Alex R. Bautista

This paper introduces a single-cell proteomics pipeline for analyzing human microglia, identifying 1039 proteins per cell and revealing mitochondrial protein variation across subtypes.

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

The paper uses HDAC inhibitors to mimic human DAM in vitro and identifies shared marker genes.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

The paper compares epifluorescence, immunofluorescence, and immunohistochemistry for assessing viral-mediated gene expression in macaques, finding that the latter two methods detect more transduced neurons and provide better visualization.

This study shows that inactivating the superior colliculus in monkeys alters perceptual decision-making, supporting the embodied cognition model by linking decision evidence accumulation to a brainstem structure.