Vladislav Petyuk

Multiomics dissection of the CO2-dependent fast growth of Picochlorum celeri

This study profiles multi-omics data in Picochlorum celeri under CO2 limitation, revealing a CO2-dependent switch in Rubisco subunits and extensive post-translational modifications.

Improved surfactant-assisted one-pot sample preparation for robust convenient single cell proteomics

This paper introduces an improved single-cell proteomics method, iSOP-MS, which enhances robustness and convenience for quantitative analysis by using a low-volume 384-well plate and optimized enzyme mixtures.

Detection of Melanoma Using Deep Serum Proteome Profiling and Machine Learning

This study detects melanoma using serum proteome profiling and machine learning, identifying eight protein biomarkers with high diagnostic accuracy.

Single-cell nanodroplet processing proteomics pipeline for analysis of human-derived microglia

This paper introduces a single-cell proteomics pipeline for analyzing human microglia, identifying 1039 proteins per cell and revealing mitochondrial protein variation across subtypes.

Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors

This study uses phosphoproteomics to analyze signaling dynamics in neuronal cells stimulated with insulin and IGFs, identifying key phosphorylation events and pathways involved in actin cytoskeletal regulation.

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

A proteogenomic tool uncovers protein markers for human microglial states

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits

The paper examines associations between three multi-omic AD subtypes and four psychological traits, finding differential links between subtypes and traits.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes

The paper compares cerebrospinal fluid proteomes of ME/CFS patients with and without fibromyalgia, finding no significant differences, suggesting they may not be distinct conditions.

A general technique for the detection of switch-like bistability in chemical reaction networks governed by mass action kinetics with conservation laws

The paper develops a generalized method to detect switch-like bistability in chemical reaction networks with conservation laws, validated on known bistable motifs.

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

The paper uses multiplexed proteomics to identify synaptic factors linked to cognitive resilience in Alzheimer's Disease by analyzing brain tissue from individuals with varying pathology and cognitive outcomes.

A Consensus Proteomic Analysis of Alzheimer's Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation

The paper identifies protein network modules in Alzheimer's disease brains and cerebrospinal fluid that are associated with energy metabolism and neuroinflammation, suggesting potential biomarkers and therapeutic targets.

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

The paper examines microglial activation in elderly brains, finding strong associations with neuropathology and cognitive decline, and identifies genetic overlaps with Alzheimer's disease.