Yuka Sakata

This study generates human fetal zone adrenal cortex-like cells from induced pluripotent stem cells, revealing key signaling pathways and transcription factors involved in adrenocortical specification and steroidogenesis.

The paper identifies the adrenal cortex's origin in adrenogenic coelomic epithelium, distinct from gonadogenesis, in humans and cynomolgus monkeys.

This study establishes an in vitro protocol to generate human prospermatogonia-like cells from induced pluripotent stem cells and characterizes their lineage trajectory using single-cell RNA-sequencing.