Keren Cheng

Generation of spermatogonia from pluripotent stem cells in humans and non-human primates

This study generates spermatogonia from human and non-human primate pluripotent stem cells using xenogeneic testes, providing models for male infertility research.

Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian Cancer

The paper identifies fallopian tube progenitors as potential precursors of high-grade serous ovarian cancer by integrating transcriptomic data from normal and malignant tissues.

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

This study maps seminoma transcriptomes and epigenetic features to the normal human germline trajectory, revealing similarities to primordial germ cells and identifying gene dosage effects in a patient-derived model.

Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells

This study establishes methods to generate marmoset primordial germ cell-like cells from iPSCs, revealing a primate-specific germline transcriptional network and potential for in vitro gametogenesis modeling.

Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

This study generates human fetal zone adrenal cortex-like cells from induced pluripotent stem cells, revealing key signaling pathways and transcription factors involved in adrenocortical specification and steroidogenesis.

The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

The paper identifies the adrenal cortex's origin in adrenogenic coelomic epithelium, distinct from gonadogenesis, in humans and cynomolgus monkeys.

Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis

This study identifies distinct epigenetic programming in regenerative spermatogonial stem cells and progenitors in mouse testis using integrative epigenomic analysis.