Matthew J. Dysart

The paper demonstrates how to use orthogonal trans-splicing ribozymes to store and report on multiple plasmid-encoded traits in microbial communities using RNA barcoding.

The paper introduces Ribodesigner, a tool to design catalytic RNAs that selectively barcode specific taxonomic groups, demonstrating increased selectivity over broad host range designs.

The paper uses a synthetic ribozyme to detect phage-host interactions in microbial communities through 16S rRNA sequencing, identifying Aeromonadales as a novel host for phage P1.

The paper uses synthetic RNA to store and detect information in microbial communities through rRNA sequencing, revealing differences in information storage across variants.

The paper identifies missense variants in PLS3 causing X-linked congenital diaphragmatic hernia and body wall defects through genetic analysis and functional studies.