Lauren B. Stadler

Microfluidic Capture-Enrichment of individualized microbes from urban wastewater reveals a hidden reservoir of potential pre-emergent pathogens

The paper develops a microfluidic Capture-Enrichment pipeline to identify potential pre-emergent pathogens in urban wastewater, revealing clinically relevant threats and emerging phenotypes.

Storing >1 byte of information in 16S ribosomal RNA using orthogonal trans-splicing ribozymes

The paper demonstrates how to use orthogonal trans-splicing ribozymes to store and report on multiple plasmid-encoded traits in microbial communities using RNA barcoding.

Biocontainment attenuation of mobile DNA host range in a wastewater microbiome

The paper evaluates how toxin-based biocontainment systems affect horizontal gene transfer in a wastewater microbiome using orthogonal catalytic RNA to track plasmid host range and persistence.

Seqwin: Ultrafast identification of signature sequences in microbial genomes

Seqwin identifies microbial signature sequences by analyzing large genome collections, outperforming existing methods in efficiency and quality.

Rational engineering enhances the signal and modularity of an RNA barcoding technology to track gene transfer in microbiomes

The paper improves an RNA barcoding technology for tracking gene transfer in microbiomes by enhancing signal strength and modularity.

Controlling the taxonomic composition of biological information storage in 16S ribosomal RNA

The paper introduces Ribodesigner, a tool to design catalytic RNAs that selectively barcode specific taxonomic groups, demonstrating increased selectivity over broad host range designs.

Cross-order detection of bacteriophage transduction in communities using ribosomal RNA barcoding

The paper uses a synthetic ribozyme to detect phage-host interactions in microbial communities through 16S rRNA sequencing, identifying Aeromonadales as a novel host for phage P1.

Information storage across a microbial community using universal RNA memory

The paper uses synthetic RNA to store and detect information in microbial communities through rRNA sequencing, revealing differences in information storage across variants.

Comparative analysis of culture- and ddPCR-based wastewater surveillance for carbapenem-resistant bacteria

This study compares culture-based and ddPCR methods for detecting carbapenem-resistant bacteria in wastewater, finding weak correlations between quantitative results due to method sensitivity and specificity differences.

Olivar: automated variant aware primer design for multiplex tiled amplicon sequencing of pathogens

Olivar automates variant-aware primer design for tiled amplicon sequencing of pathogens, improving mapping rates and coverage compared to existing methods.

Long duration environmental biosensing by recording analyte detection in DNA using recombinase memory

This paper develops recombinase-memory biosensors to record analyte detection in DNA over long durations, demonstrating their use in wastewater isolates.