Developmental BiologybioRxivPreprint
Oncogenic MAPK pathway activation disrupts Schwann cell fate commitment, inducing congenital and progressive neuropathy in mice
Elise Maréchal, Daniel Aldea, Patrice Quintana…·Heather Etchevers
This study shows that oncogenic MAPK pathway activation in Schwann cells causes congenital and progressive neuropathy in mice, linking RASopathy mutations to peripheral nerve dysfunction.
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