Philip Tinnefeld

This paper introduces MARs, magnetic molecular nanorulers that measure molecular distances and enable combinatorial biosensing with high accuracy and resolution.

This paper introduces an AI-based framework for designing responsive protein oligomers that assemble in response to chemical or phosphorylation triggers, validated through experimental testing.

This study observes sub-microsecond dynamics of single DNA molecules using graphene-based fluorescence measurements and links findings to structural and environmental factors.

This paper introduces reconfigurable DNA origami arrays as a network of two-state systems to enable multi-stimuli, multi-output nanorobots with controlled logic and timing.

This paper introduces Brownian DNA computing, a molecular computing framework that uses DNA origami scaffolds to implement logic gates and circuits through thermal fluctuations, enabling energy-efficient and reversible computation.

This study localizes Myosin A in Toxoplasma gondii with 1-4 nm axial precision using graphene energy transfer, supporting the linear migration motor model.

This paper introduces a sensitive, non-amplified nucleic acid detection method using DNA origami nanoantennas, achieving attomolar detection without requiring molecular amplification.

The paper introduces a molecular fluorescence lifetime sensor to non-invasively monitor DNA origami coating with cationic polymers or silica in real-time at the single nanostructure level.

This paper infers binding and unbinding rates from fluorescence time series while accounting for photobleaching using a two-stage Bayesian approach.

This paper develops a fluorescent probe to detect malaria-infected red blood cells and demonstrates its use with a smartphone microscope for diagnostic applications.

This paper develops a DNA-mediated photostabilization method for single-molecule and super-resolution imaging, showing improved performance at lower additive concentrations and enabling continuous replenishment of photostabilizers.

The paper introduces a method to create light-activatable DNA processing enzymes and demonstrates their performance in molecular biology assays.