The paper uses fluorescence labeling to study how maternal organelles are inherited and recycled during Toxoplasma gondii replication, identifying three modes of inheritance and a role for Myosin F in redistribution.

bioRxiv · Aug 15, 2025 · PreprintCell Biology

Localisation of Apicomplexa motor Myosin A with axial nanometric precision using graphene energy transfer

Giovanni Ferrari, Yuan Song, Michael Hensel, Olympia Ekaterini Psathaki, Doan Thuy Nguyen Nguyen, Simon Gras, Markus Meissner, Philip Tinnefeld, Javier Periz

This study localizes Myosin A in Toxoplasma gondii with 1-4 nm axial precision using graphene energy transfer, supporting the linear migration motor model.

bioRxiv · Jul 30, 2025 · PreprintBiophysics

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

Mauricio J.A. Ruiz-Fernandez, Jianfei Jiang, Alice Battistella, Armina Mortazavi, Sterre van Wierst, Bingzhi Wang, Artur Kuznetcov, Rüya Aslan, Jack Merrin, Daan Vorselen, Jochen R. Guck, Markus Meissner, Javier Periz, Benedikt Sabass, Jörg Renkawitz

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

bioRxiv · May 3, 2024 · PreprintCell Biology

Toxoplasma gondii establishes an extensive filamentous network consisting of stable F-actin during replication

Javier Periz, Jamie Whitelaw, Clare Harding, Leandro Lemgruber, Simon Gras, Madita Reimer, Robert Insall, Markus Meissner

This study shows Toxoplasma gondii forms stable F-actin networks in vivo, essential for replication and vesicle exchange between parasites.

eLife · Mar 21, 2017Peer-reviewedCell Biology