Raghavendra Selvan

This study shows that stabilizing V1 interneuron-motor neuron connectivity in ALS mice improves motor function by enhancing motor neuron survival.

The paper investigates spinal interneuron degeneration in an ALS mouse model, finding inhibitory neurons degenerate earlier and more slowly than excitatory neurons and motor neurons.

The paper shows that loss of inhibitory synapses from V1 interneurons onto fast motor neurons precedes ALS progression and contributes to locomotor deficits.