Ole Kiehn

The paper introduces a tissue-clearing framework and mesoSPIM-ultra system for large-scale single-neuron tracing in cleared mouse tissue.

This paper identifies a hypothalamus-brainstem circuit that prioritizes safety over essential needs by modulating locomotion behavior.

The paper investigates spinal interneuron degeneration in an ALS mouse model, finding inhibitory neurons degenerate earlier and more slowly than excitatory neurons and motor neurons.

The paper shows that loss of inhibitory synapses from V1 interneurons onto fast motor neurons precedes ALS progression and contributes to locomotor deficits.

The paper identifies Chx10-lineage reticulospinal neurons that control left/right locomotor asymmetries in mammals through ipsilateral and contralateral projections.

This study generates oculomotor neurons from mouse stem cells and shows they are more resilient to ALS-like toxicity than spinal motor neurons.