Ilary Allodi

The paper develops a spiking neural network model of spinal circuits to predict optimal therapeutic windows for ALS intervention by analyzing the effects of V1 interneuron stabilization.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.

This study shows that stabilizing V1 interneuron-motor neuron connectivity in ALS mice improves motor function by enhancing motor neuron survival.

The paper investigates spinal interneuron degeneration in an ALS mouse model, finding inhibitory neurons degenerate earlier and more slowly than excitatory neurons and motor neurons.

The paper shows that loss of inhibitory synapses from V1 interneurons onto fast motor neurons precedes ALS progression and contributes to locomotor deficits.

This study uses LCM-seq to analyze transcriptional changes in SMA, identifying cell-type specific adaptations that explain resistance in ocular motor neurons.

This study investigates excitability of spinal motoneurones in G93A SOD1 ALS mice and finds no deficits in repetitive firing, but increased input responsiveness and persistent inward currents.

This study generates oculomotor neurons from mouse stem cells and shows they are more resilient to ALS-like toxicity than spinal motor neurons.