Manuela Büettner

This study compares 2D and 3D gut-on-chip models to assess how epithelial architecture affects responses to microbial challenges.

The paper develops a human intestinal organoid co-culture model with macrophages to study bacterial infection control, finding that activated macrophages reduce bacterial burden and cytotoxicity.

This study shows that rearing environment significantly affects the phenotype of genetically identical mice, influencing gut microbiota, body weight, behavior, and epigenetic patterns.