Matthias Lochner

A gut-on-chip model reveals architecture-dependent epithelial responses to microbial challenge

This study compares 2D and 3D gut-on-chip models to assess how epithelial architecture affects responses to microbial challenges.

Canonical Notch2 Signaling Regulates the Development of Iron-recycling Macrophages and Iron Homeostasis

Activated macrophages restrict invasive bacterial infection in a human intestinal organoid co-culture model

The paper develops a human intestinal organoid co-culture model with macrophages to study bacterial infection control, finding that activated macrophages reduce bacterial burden and cytotoxicity.

HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

This study identifies HIF-1α as a regulator of metabolic and immunoregulatory programs in RORγt⁺ Tregs during intestinal inflammation, showing its role in maintaining suppressive function and limiting inflammation.

Human ILC methylomes uncover stable lineage codes and disease-linked ILC2 regulators in allergy

This study maps DNA methylation patterns in human ILC subsets, identifies disease-linked regulators in ILC2, and shows their role in allergic inflammation.