Qi Cao

This study shows PARP1 prevents TOP1 from causing deletions at STRs by inhibiting TOP1-DNA adduct formation, which could inform therapies for cancers with RNase H2 mutations.

Deep-Chopper detects and removes adapter sequences from nanopore dRNA-seq reads, improving transcriptome analysis accuracy.

The paper introduces MACMIC, a method to identify feature pairs with maximal colocalization and minimal correlation, revealing CTCF's dual role in regulating cell identity genes through epigenetic mechanisms.