YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs
Nana Chen, Gracia M. Bonilla, Abdullah Al Emran, Brian Lin, Haymanti Bhanot, Yang Sun, Avinash Waghray, Mateo Useche, David Liu, Genevieve Marie Boland, Ivana L. de la Serna, Valentina Sancisi, Martin Sattler, Jayaraj Rajagopal, Xu Wu, , Srinivas Vinod Saladi
This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.
bioRxiv · Sep 10, 2025 · PreprintCancer Biology