Gracia M. Bonilla

A positively selected microRNA controls a reversible aging program in striated muscle

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs

This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.

Microglial depletion decreases Müller cell maturation and inner retinal vascular density

This study shows that microglia depletion reduces Müller cell maturation and inner retinal vascular density in mice.

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

Multiomic analysis of clonal development reveals new regulators of leukemic cell growth

The paper uses multiomic analysis of leukemic clones in a mouse model to identify growth regulators and validate their roles in AML.

Complement facilitates developmental microglial pruning of astrocyte and vascular networks

This study shows that microglial complement signaling regulates astrocyte pruning and vascular development in the retina.