Brian Lin

This study shows that induced microfold cells are essential for the function of pulmonary tertiary lymphoid organs, which support mucosal immunity against influenza.

EpiRank evaluates epitope prediction by ranking surface patches on single-chain geometry, finding it correctly identifies real epitopes 64% of the time but with significant baseline overlap.

This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.

The paper shows that disrupting epigenetic barriers in olfactory placode-derived cells can induce stem cell-like characteristics through genetic perturbations.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.