AxSpA joint tissue is characterised by HLA-DR+ tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)+ CD8+ T cell subsets
Feng Liu, Hui Shi, Jiewei Chen, Benjamin J. L. Kendrick, Dajiang Du, Paul Bowness, Qiang Tong, Liye Chen
This study profiles CD8+ T cells in AxSpA synovium using scRNA-seq, identifying HLA-DR+ TRM and KIR+ subsets with distinct transcriptional features and potential pathogenic roles.
bioRxiv · Oct 9, 2024 · PreprintImmunology