CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue
Feng Liu, Hui Shi, Jason D. Turner, Rachel Anscombe, Jiaqi Li, Takuya Sekine, Ariane Hammitzsch, Devika Agarwal, Christopher B. Mahony, Jiewei Chen, Benjamin J. L. Kendrick, Dajiang Du, Qiang Tong, Lihua Duan, Kyla Dooley, , Liye Chen
This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.
Annals of the Rheumatic Diseases · May 23, 2025Peer-reviewedImmunology