Paul Bowness

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein

The paper investigates shared and distinct functional pathogenicity of gut microbiomes in inflammatory diseases using germ-free mice colonized with human fecal samples.

AxSpA joint tissue is characterised by HLA-DR+ tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)+ CD8+ T cell subsets

This study profiles CD8+ T cells in AxSpA synovium using scRNA-seq, identifying HLA-DR+ TRM and KIR+ subsets with distinct transcriptional features and potential pathogenic roles.

Trained immunity in human monocyte enhances myeloid-T-cell pathogenic crosstalk in Ankylosing Spondylitis

The paper identifies trained immunity in AS monocytes and shows their enhanced response to T-cell activation, contributing to Th17 responses and disease pathology.

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of RUNX3 promoter

The paper investigates how genetic variants associated with ankylosing spondylitis affect c-MYC binding and chromosomal looping near the RUNX3 promoter.

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele

The paper investigates how a genetic variant affects IL7R expression and soluble receptor secretion in monocytes under inflammatory conditions.