Christine Biben

The paper compares functional properties of fetal and adult hematopoietic stem/progenitor cells through transplantation, revealing differences in lineage bias and clonal multi-lineage differentiation.

This study evaluates sample multiplexing reagents and protocols for scRNA-Seq, finding that workflow improvements and reagent choice impact data quality and cost-effectiveness.

The paper develops LoxCode barcoding to trace clonal fate of epiblast cells in vivo, finding lineage biases and tissue-specific contributions across fetal development.

The paper uses flow cytometry to analyze the role of Wt1 in epicardial development, finding that Wt1 is essential for formation and maintenance rather than promoting mesenchymal transition.

scPipe provides a flexible R/Bioconductor pipeline for preprocessing scRNA-seq data, handling multiple barcoding strategies and generating quality reports for downstream analysis.