Andrew J. Kueh

This study shows that SMCHD1's weak DNA binding is essential for its chromatin retention and function, revealing how DNA binding affects its localization and gene repression.

This paper introduces Partita, a high-density CRISPRa platform for comprehensive gene activation studies, demonstrating its utility in identifying cancer dependencies and resistance pathways in vitro and in vivo.

This study identifies renal mononuclear phagocytes as an intracellular reservoir for UPEC in pyelonephritis, showing that complement receptor-mediated entry promotes bacterial persistence and limits β-lactam efficacy.

This study compares three RIPK3 kinase-dead variants to show that their scaffolding functions differ based on kinase domain conformation, not just kinase activity, and highlights implications for inhibitor development.

The paper investigates DNA repair pathways that protect against methylation damage, showing that Mbd4 and MutSα cooperate to prevent spontaneous deamination of 5-methylcytosine.

This study identifies ARAP2 as a regulator of IFN-gamma signaling by modulating SOCS1 function through a phosphorylation-dependent interaction.

This study shows DNMT3A mutations reduce DNA methylation and disrupt p53 pathway, increasing self-renewal and cancer risk in hematopoietic cells.

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.

The paper develops LoxCode barcoding to trace clonal fate of epiblast cells in vivo, finding lineage biases and tissue-specific contributions across fetal development.

This study identifies VDAC2 as essential for BAX-mediated apoptosis and tumor suppression, showing BAX and BAK are differentially regulated.