Simone Mazzaferro

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

This study shows that an anti-obesity neuropeptide analogue promotes adult neurogenesis and rescues neuronal survival in diet-induced obesity.

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.