Andrian Yang

A Community-Driven Single-Cell PBMC Reference Integrating Landmark Datasets Spanning Health and Disease

HARP integrates PBMC data from multiple studies to create a reference atlas with consensus annotations and identifies age, sex, and disease-related cellular modules.

Single-Cell Proteo-Transcriptomic Profiling Uncovers Post-Translational Regulatory Layers in Human Hematopoiesis

This paper uses single-cell proteo-transcriptomic profiling to reveal post-translational regulatory mechanisms in human hematopoiesis, showing that protein-RNA correlations and transcription factor dynamics provide insights into lineage commitment and fate decisions.

GLP-1R agonists activate human hypothalamic neurons

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

A reference induced pluripotent stem cell line for large-scale collaborative studies

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

Inter-gastruloid heterogeneity revealed by single cell transcriptomics time course: implications for organoid based perturbation studies

The paper uses single-cell RNA-sequencing to study heterogeneity in mouse gastruloids over time, revealing distinct mesodermal and neural differentiation trajectories and their implications for perturbation studies.

Transposable element expression at unique loci in single cells with CELLO-seq

The paper introduces CELLO-seq, a long-read RNA sequencing method for single cells, to study TE expression in mouse and human cells, finding locus-specific expression and regulatory heterogeneity.

starmapVR: immersive visualisation of single cell spatial omic data

starmapVR provides an immersive visualization tool for single-cell and spatial omic data using VR, supporting 3D and 2.5D views with multiple interaction methods.

Scavenger: A pipeline for recovery of unaligned reads utilising similarity with aligned reads

Scavenger recovers unaligned RNA-seq reads using aligned reads' information, improving gene expression analysis and revealing pseudogene expression impacts.

starmap: Immersive visualisation of single cell data using smartphone-enabled virtual reality

starmap provides a VR tool for immersive visualization of single-cell data using smartphones and low-cost VR devices.

PBrowse: A web-based platform for real-time collaborative exploration of genomic data

PBrowse enables real-time collaborative exploration of genomic data through a web-based platform with integrated file sharing and discussion features.

Falco: A quick and flexible single-cell RNA-seq processing framework on the cloud

Falco accelerates and reduces the cost of scRNA-seq analysis by parallelizing pipelines on cloud infrastructure.