Hsiao‐Jou Cortina Chen

This study maps region-specific histopathological features of scrapie-induced neurodegeneration in mouse brain regions at early and late disease stages, identifying key markers and region-specific mechanisms.

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

This study shows that an anti-obesity neuropeptide analogue promotes adult neurogenesis and rescues neuronal survival in diet-induced obesity.

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.