Author

Dominique Lagasca

The University of Texas Southwestern Medical CenterORCID 0000-0003-4404-4366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Kendra K. FrederickiD· 3 shared Yiling XiaoiD· 3 shared Rania DumariehiD· 2 shared Sakshi KrishnaiD· 2 shared Shoyab AnsariiD· 2 shared Jaka KrageljiD· 1 shared Rupam GhoshiD· 1 shared Yang LiiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

Kendra K. FrederickORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural context modulates the conformational ensemble of the intrinsically disordered amino terminus of α-synuclein

Rania Dumarieh, Dominique Lagasca, Sakshi Krishna, Jaka Kragelj, Yiling Xiao, Shoyab Ansari, Kendra K. Frederick

This study shows that the conformational behavior of α-synuclein's disordered amino terminus varies depending on its structural context and environmental conditions.

Journal of the American Chemical Society · Mar 27, 2025Peer-reviewedBiophysics

Stability of the polarization agent AsymPolPOK in intact and lysed mammalian cells

Dominique Lagasca, Rupam Ghosh, Yiling Xiao, Kendra K. Frederick

This study evaluates AsymPolPOK's stability and performance as a polarization agent in mammalian cells, showing its effectiveness with electroporation but limitations due to rapid reduction in the cellular environment.

Journal of Magnetic Resonance · Nov 11, 2024Peer-reviewedBiophysics

Intact cells selectively amplify and structurally remodel amyloid fibrils

Shoyab Ansari, Dominique Lagasca, Rania Dumarieh, Yiling Xiao, Sakshi Krishna, Yang Li, Kendra K. Frederick

This study shows that intact cells selectively amplify and remodel amyloid fibrils of α-synuclein, unlike in vitro or lysate systems.

bioRxiv · Sep 9, 2024 · PreprintBiophysics