Author

Shoyab Ansari

The University of Texas Southwestern Medical CenterORCID 0009-0009-0446-528XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Dominique LagascaiD· 2 shared Kendra K. FrederickiD· 2 shared Rania DumariehiD· 2 shared Sakshi KrishnaiD· 2 shared Yiling XiaoiD· 2 shared Jaka KrageljiD· 1 shared Yang LiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

Dominique LagascaORCID

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2 papers

Recent·Most cited

Structural context modulates the conformational ensemble of the intrinsically disordered amino terminus of α-synuclein

Rania Dumarieh, Dominique Lagasca, Sakshi Krishna, Jaka Kragelj, Yiling Xiao, Shoyab Ansari, Kendra K. Frederick

This study shows that the conformational behavior of α-synuclein's disordered amino terminus varies depending on its structural context and environmental conditions.

Journal of the American Chemical Society · Mar 27, 2025Peer-reviewedBiophysics

Intact cells selectively amplify and structurally remodel amyloid fibrils

Shoyab Ansari, Dominique Lagasca, Rania Dumarieh, Yiling Xiao, Sakshi Krishna, Yang Li, Kendra K. Frederick

This study shows that intact cells selectively amplify and remodel amyloid fibrils of α-synuclein, unlike in vitro or lysate systems.

bioRxiv · Sep 9, 2024 · PreprintBiophysics