Emma J. Fenech

This paper uses cryo-EM to reveal the assembly mechanism of mitochondrial complex III and supercomplex CIII2CIV, showing that subunit incorporation and folding are uncoupled and assembly proceeds non-parallel after dimerization.

The paper presents a cryo-EM structure of the EMC:Spf1 supercomplex, showing how it integrates TMD insertion and dislocation activities for membrane protein quality control.

The paper profiles the LAM family of contact site tethers to understand their localization and function, revealing unique and shared roles through proximity labeling.

The paper identifies an amphipathic helix as a targeting motif for ER surface proteins in yeast and humans, showing its conservation and role in membrane localization.

The paper develops ABOLISH, a method to reduce endogenous biotinylation in yeast, enabling more accurate detection of both stable and transient protein interactions using biotin ligases.