Andrea Gottinger

Cryo-EM reveals the central steps of mitochondrial complex III assembly and the cooperative assembly of supercomplex CIII2CIV

This paper uses cryo-EM to reveal the assembly mechanism of mitochondrial complex III and supercomplex CIII2CIV, showing that subunit incorporation and folding are uncoupled and assembly proceeds non-parallel after dimerization.

COQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating

This study identifies COQ8 as a chaperone that facilitates coenzyme Q biosynthesis by ATP-driven structural gating of intermediates.

L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis

The paper identifies L2HGDH as a component of the COQ metabolon, linking L-2-hydroxyglutarate recycling to coenzyme Q biosynthesis and showing its role in maintaining biosynthetic intermediates.

Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesisvia Substrate Channeling

The paper investigates how metabolon clustering enhances coenzyme Q biosynthesis through substrate channeling using simulations and experiments.

The glycine-arginine-rich motif of 53BP1 modulates RNA interactions necessary for its liquid-liquid phase separation during DNA Damage Response

This study identifies the glycine-arginine-rich motif of 53BP1 as essential for RNA interactions and phase separation during DNA damage response, showing its role in DNA repair.

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.