Sungjin Park

This study reveals novel extracellular matrix (ECM) structures around excitatory neurons using HaloTag-HAPLN1, showing spatial and temporal regulation of ECM deposition and heterogeneity among neuronal populations.

The paper identifies two distinct release modes of alpha-tectorin (TECTA) mediated by microvilli and proteolytic shedding, which determine domain-specific matrix organization in the tectorial membrane.

This paper introduces a secreted reporter assay to quantitatively and longitudinally monitor neuronal activity in cultured neurons, enabling cell type-specific analysis and pharmacological response profiling.

This study identifies proteolytic shedding as the primary mechanism for releasing GPI-anchored GPC4 from astrocytes, with ADAM9 mediating part of this process.