Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity
Dong Uk Yang, Yu Wang, Tianbo Qi, Xi Zhang, Leyao Shen, Jingrui Ma, Zhengyuan Pang, Neeraj K. Lal, Daniel B. McClatchy, Saba Heydari Seradj, Verina H. Leung, Kristina Wang, Yi Xie, Filip S. Polli, Anton Maximov, , Ye Li
The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.
Neuron · Jan 23, 2024Peer-reviewedNeuroscience