Leyao Shen

Learning Shapes the Energy Cost of Neural Tasks

The paper measures the energy cost of learning-based tasks in mice and finds that post-learning fuel consumption decreases, suggesting energy minimization during learning.

Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation.

The paper identifies SLC38A2 as essential for proline supply during osteoblast differentiation and bone formation, showing its role in proline-rich protein synthesis.

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.