Molecular BiologyNature CommunicationsPeer-reviewed
Reprogramming the Rossmann Fold Signature Motif Creates Orthogonal Redox Biocatalysts
Yu Ping, Jin Young Kim, Minh-Anh L. Dinh…·Han Li
The paper reprograms the Rossmann fold motif to create NMN+-specific enzymes that avoid NAD(P)/H interactions, achieving high specificity and productivity in biotransformation.
DOI 10.1038/s41467-026-77633-7