NeuroscienceAging CellPeer-reviewed
Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy
Maheedhar Kodali, Leelavathi Narayana Madhu, Yogish Somayaji…·Ashok Kumar Shetty
This study examines the effects of short-term CSF1R inhibition in 5xFAD mice, showing reduced microglia, noninflammatory phenotype, and altered signaling pathways without affecting Aβ plaques.
17 citations