Author

Yogish Somayaji

Texas A&M Health Science CenterORCID 0000-0002-8946-1633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Ashok Kumar ShettyiD· 3 shared Bing Shuai· 3 shared Leelavathi Narayana MadhuiD· 3 shared Maheedhar KodaliiD· 3 shared Sahithi Attaluri· 3 shared Shama Rao· 3 shared Goutham ShankariD· 2 shared Raghavendra UpadhyaiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Ashok Kumar ShettyORCID

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3 papers

Recent·Most cited

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged Hippocampus

Leelavathi Narayana Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok Kumar Shetty

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

bioRxiv · Mar 2, 2025 · PreprintNeuroscience

Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy

Maheedhar Kodali, Leelavathi Narayana Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny Jaimes Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok Kumar Shetty

This study examines the effects of short-term CSF1R inhibition in 5xFAD mice, showing reduced microglia, noninflammatory phenotype, and altered signaling pathways without affecting Aβ plaques.

Aging Cell · Nov 21, 2024Peer-reviewedNeuroscience

Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model

Leelavathi Narayana Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J. Cai, Ashok Kumar Shetty

This study shows that intranasally administered EVs from hiPSC-derived NSCs reduce microglial activation and improve brain function in an Alzheimer's model.

Journal of Extracellular Vesicles · Nov 1, 2024Peer-reviewedNeuroscience