Goutham Shankar

This study shows that extracellular vesicles from hiPSC-derived neural stem cells protect human neurons from Aβ-42 oligomer-induced neurodegeneration, mitochondrial dysfunction, and tau phosphorylation.

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

This study examines the effects of short-term CSF1R inhibition in 5xFAD mice, showing reduced microglia, noninflammatory phenotype, and altered signaling pathways without affecting Aβ plaques.

The paper uses single-molecule long-read sequencing to identify conserved long RNA profiles in sperm and reveals a post-transcriptional selection mechanism shaping these profiles in mice and humans.