Vance Lemmon

This paper identifies GAK as a novel mitotic kinase and therapeutic target in DLBCL, showing that GAK inhibition causes mitotic defects and that existing drugs can be repurposed for its targeting.

The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.

This paper develops and validates a lumbar intrathecal catheterization method in rats for reliable drug delivery to the brain and confirms supraspinal pharmacodynamic target engagement.

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.