Andrea Thorn

The paper uses AlphaFold2 and experimental methods to determine new domains in SARS-CoV-2 nsp3, revealing a previously unknown folded domain and suggesting a function for a conserved domain in viral pore assembly.

This paper discusses the impact of AlphaFold2 on structural biology, highlighting its accuracy and applications while noting its limitations in predicting conformational variability and posttranslational modifications.

The paper describes the rapid structural determination of SARS-CoV-2 proteins during the pandemic and the efforts to evaluate and improve these structures for drug and vaccine development.

The paper introduces Haruspex, a convolutional neural network that automatically annotates Cryo-EM maps for protein secondary structures and RNA/DNA, achieving high recall and precision on test data.