Agnel Praveen Joseph

DPI-score: A deep learning-based metric for assessing protein-protein interfaces in cryo-EM derived assemblies

The paper introduces DPI-Score, a deep learning metric to assess protein-protein interfaces in cryo-EM structures, showing it can detect interface errors not found by density-based scores.

Automated filtering of particle images in single particle cryoEM

This paper introduces a deep learning method to improve single particle cryoEM data quality by automatically filtering noisy images using denoising and domain adaptation neural networks.

Structural basis of unidirectional DNA recombination by the ΦC31 serine integrase

This paper reports structures of ΦC31 integrase in complexes with DNA recombination sites, elucidating the structural basis of its unidirectional recombination mechanism.

Assessment of protein-protein interfaces in cryo-EM derived assemblies

The paper introduces PI-score, a machine learning-based metric to assess protein-protein interfaces in cryo-EM-derived assemblies, identifying errors not captured by density-based methods.

Making the invisible enemy visible

The paper describes the rapid structural determination of SARS-CoV-2 proteins during the pandemic and the efforts to evaluate and improve these structures for drug and vaccine development.

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

The paper examines the genetic diversity of CHC22 clathrin and its impact on glucose metabolism, finding that a variant is less effective at controlling GLUT4 traffic and is more common in farming populations.

PBxplore: A Tool To Analyze Local Protein Structure And Deformability With Protein Blocks

PBxplore analyzes protein structure and deformability using Protein Blocks, providing outputs like frequencies and entropy from molecular dynamics simulations.