Tristan Ian Croll

Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum

The paper identifies a third mode of IRE1 activation called TRES, triggered by reduced protein influx into the ER, leading to a distinct gene expression program to rebalance ER load.

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

Likelihood-based interactive local docking into cryo-EM maps in ChimeraX

The paper introduces a likelihood-based local docking method for cryo-EM maps, improving speed and sensitivity when component locations are known, implemented in ChimeraX.

Structures of full-length glycoprotein hormone receptor signaling complexes

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

Making the invisible enemy visible

The paper describes the rapid structural determination of SARS-CoV-2 proteins during the pandemic and the efforts to evaluate and improve these structures for drug and vaccine development.