Romano Regazzi

TRMT10A deficiency and tRNA fragmentation disrupt human pancreatic β-cell identity and insulin maturation

This study shows TRMT10A deficiency causes β-cell dysfunction by promoting tRNA fragmentation and disrupting PCSK1 expression, leading to impaired insulin maturation and glucose-stimulated insulin secretion.

5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes

This study identifies 5'tRNA-derived fragments as mediators of β-cell dysfunction and islet macrophage activation in type 2 diabetes.

The MIME-seq technique allows to monitor the interaction of small non-coding RNAs with Argonaute proteins and their transfer to other cells

The MIME-seq technique protects small non-coding RNAs from oxidation to enable detection of their interaction with Argonaute proteins and transfer between cells.

Role of small intronic RNAs in the crosstalk between immune cells and beta-cells during type 1 diabetes development

The paper identifies two small intronic RNAs, sinR-D and sinR-T, that are transferred between immune cells and beta-cells in type 1 diabetes, with sinR-D promoting beta-cell apoptosis.

3'tRNAAsp(GTC)-derived fragment links inflammation to post-transcriptional reprogramming in chondrocytes during osteoarthritis.

This study identifies 3'tRNAAsp(GTC)-derived fragment as a regulator linking inflammation to translational reprogramming in chondrocytes during osteoarthritis.

Small non-coding RNA profiling reveals inflammatory and mitochondrial related changes in aging β-cells and islet macrophages

This study profiles small non-coding RNAs in aging β-cells and islet macrophages, identifying age-related changes in miRNAs and tRFs linked to inflammation and mitochondrial function.

Chromatin accessibility variations across pancreatic islet maturation

The paper identifies Scrt1 as a novel transcriptional repressor controlling β-cell proliferation by analyzing chromatin accessibility in newborn versus adult rat islets using ATAC-seq.