Author

Mark T.A. Donoghue

Memorial Sloan Kettering Cancer CenterORCID 0000-0003-4538-6069Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Chaitanya BandlamudiiD· 2 shared Sarat ChandarlapatyiD· 2 shared Allen J. YorkiD· 1 shared Anna MalkovaiD· 1 shared Anton Mikhailovich SafonoviD· 1 shared Antonio MarraiD· 1 shared Aziz SancariD· 1 shared Ben O’LearyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Chaitanya BandlamudiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 18, 2025

Carcinogen-induced DNA adducts amplify APOBEC mutagenesis through nucleotide excision repair

Cameron C. Durfee, Bojana Stefanovska, Rongjie Wu…·Reuben S. Harris

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

4 citations

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 5, 2024

Tumor suppressor heterozygosity and homologous recombination deficiency mediate resistance to front-line therapy in breast cancer

Anton Mikhailovich Safonov, Antonio Marra, Chaitanya Bandlamudi…·Pedram Razavi

The paper identifies how germline and somatic mutations interact to cause resistance to CDK4/6 inhibitors in breast cancer and proposes a sequential treatment strategy using PARP inhibitors.

18 citations

humanwhole-exome sequencing

𝕏 PostBluesky