Allen J. York

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

This study shows human APOBEC3B does not restrict murine papillomavirus MmuPV1 replication in cellulo or in vivo, suggesting papillomaviruses have evolved mechanisms to evade this antiviral factor.

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.