Aziz Sancar

This study evaluates the combination of TMZ and EdU in treating GBM, showing improved antitumor efficacy in vitro and in preclinical models.

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

The paper uses tXR-seq to study AFB1-induced DNA repair in the human genome, finding that 3D organization influences repair efficiency and that transcription-coupled repair is dominant.

The paper uses XR-seq to map transcription events in C. elegans by analyzing repair in XPC mutants, revealing previously unrecognized transcription sites.

The paper compares UV repair efficiency and patterns between humans and mouse lemurs, finding similar repair mechanisms but differences in efficiency.

The paper evaluates seven circadian rhythm detection algorithms using empirical datasets and simulations, providing guidelines for selecting methods based on data characteristics.

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.

The paper identifies UV-induced DNA repair hotspots in the human genome using XR-seq and Damage-seq, showing they are associated with chromatin states and early-replication domains.