Masaki Sone

The paper shows that Bergmann glia-like progenitors (BGLPs) progressively restrict their lineage potential during postnatal cerebellar development, producing fewer cell types over time.

The paper uses Xenium spatial transcriptomics to identify mRNAs localized in neuronal and glial processes of the adult mouse cerebellum, finding 126 candidate genes with process-like localization patterns.

The paper integrates transcriptomic and proteomic data from mTOR-related epilepsy patients to identify impaired oxidative phosphorylation as a molecular hallmark.

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

This study identifies MEIS1 as a key transcription factor required for the development of Bergmann glia-specific properties in the cerebellum by regulating the expression of BG-specific genes.

This study characterizes Bergmann glia-like progenitors (BGLPs) in the postnatal mouse cerebellum using electroporation and spatial transcriptomics, revealing their developmental dynamics and gene expression profiles.

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.