Mikio Hoshino

Spatial transcriptomics identifies L6 corticothalamic and L6b subplate-like heterotopic neurons in an epileptogenic SLC35A2-associated brain malformation.

The paper identifies molecular features of WM heterotopic neurons in MOGHE using spatial transcriptomics and supports findings with immunohistochemistry and a mouse model.

Progressive Lineage Restriction of Bergmann Glia-like Progenitors during Postnatal Cerebellar Development

The paper shows that Bergmann glia-like progenitors (BGLPs) progressively restrict their lineage potential during postnatal cerebellar development, producing fewer cell types over time.

STING restrains calcium-dependent microglial phagocytosis and protects against neuronal loss and cognitive impairment during epileptogenesis

This study shows that STING inhibits microglial phagocytosis and protects neurons during epileptogenesis by regulating calcium signaling through the STING-STIM1-SOCE axis.

Xenium-based spatial transcriptomic screening identifies candidate mRNAs localized in neuronal and glial processes of the adult mouse cerebellum

The paper uses Xenium spatial transcriptomics to identify mRNAs localized in neuronal and glial processes of the adult mouse cerebellum, finding 126 candidate genes with process-like localization patterns.

Functional divergence of DSCAM family in vertebrates through domain-specific evolutionary pressures

This study examines the functional divergence of vertebrate DSCAM paralogs through evolutionary pressures, revealing distinct selective constraints and positive selection patterns in their intracellular domains.

Comprehensive transcriptomic and proteomic profiling of mTOR-related epilepsy

The paper integrates transcriptomic and proteomic data from mTOR-related epilepsy patients to identify impaired oxidative phosphorylation as a molecular hallmark.

The bipolar-to-multipolar transition of dendrite extension of cerebellar granule neurons requires MTCL2 to link the Golgi apparatus to the microtubule cage.

This study shows MTCL2 links the Golgi to microtubules in cerebellar granule neurons, enabling the bipolar-to-multipolar transition of dendrite extension.

Single-cell-resolved spatial multi-omics identifies mTOR-driven neuronal and astroglial pathogenicity underlying epileptogenic focal cortical dysplasia

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

MEIS1 is Required for Establishing Bergmann Glia-Specific Properties in the Developing Cerebellum

This study identifies MEIS1 as a key transcription factor required for the development of Bergmann glia-specific properties in the cerebellum by regulating the expression of BG-specific genes.

Dormant viral pathways underlie space-induced neural senescence: a neuroprotective strategy for spaceflight and neurological diseases

The paper shows that spaceflight triggers neural senescence via reactivation of dormant viral-like retroelements, and that reverse transcriptase inhibitors can reverse these effects.

Lineage Analysis and Molecular Characterization of Bergmann Glia-like Progenitors in the Postnatal Mouse Cerebellum using in vivo Electroporation and Spatial Transcriptomics

This study characterizes Bergmann glia-like progenitors (BGLPs) in the postnatal mouse cerebellum using electroporation and spatial transcriptomics, revealing their developmental dynamics and gene expression profiles.

AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons

This study identifies AUTS2's role in regulating intermediate progenitor cell division and upper-layer neuron production through interaction with PRC2 and repression of genes like Robo1.

Genetic SNUPN variants cause spinocerebellar atrophy by disrupting global splicing in Purkinje cells

The paper identifies SNUPN variants causing spinocerebellar atrophy by disrupting splicing in Purkinje cells through impaired U1 snRNP nuclear transport.

Kinesin family member Kif23 regulates cytokinetic division and maintains neural stem/progenitor cell pool in the developing neocortex

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

CyclinD1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

This study investigates the role of AUTS2 in cerebellar development, Purkinje cell maturation, and behavioral functions, finding that its loss leads to cerebellar defects and behavioral impairments linked to ASDs.

AUTS2 regulation of synapses for proper synaptic inputs and social communication.

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.