Tomoo Owa

The paper integrates transcriptomic and proteomic data from mTOR-related epilepsy patients to identify impaired oxidative phosphorylation as a molecular hallmark.

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

This study identifies MEIS1 as a key transcription factor required for the development of Bergmann glia-specific properties in the cerebellum by regulating the expression of BG-specific genes.

The paper shows that spaceflight triggers neural senescence via reactivation of dormant viral-like retroelements, and that reverse transcriptase inhibitors can reverse these effects.

This study characterizes Bergmann glia-like progenitors (BGLPs) in the postnatal mouse cerebellum using electroporation and spatial transcriptomics, revealing their developmental dynamics and gene expression profiles.

This study identifies a signaling cascade involving WNT-PROX1-CCND1-ATOH1 that regulates cerebellar granule cell progenitor proliferation and immaturity.